Sucralosa

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Sucralosa
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formula chimic: C₁₂H₁₉Cl₃O₈
Commons: Sucralose

Sucralosa[1] (E955) es un edulcorante artificial intense, discoperite in 1976. Su potere sucrante es circa 600 vices superior a isto del saccharosa. Es pauc caloric pro que le major parte ingerate non es decomponate per le corpore.

Es producite per chloration del saccharosa, reimplaciante selectivemente le gruppos hydroxy in le positiones C1, C4 e C6 pro formar un disaccharido 1,6-dichloro-1,6-didesoxyfructosa–4-chloro-4-desoxygalactosa.

Innocuitate[modificar | modificar fonte]

Sucralosa non es carcinogenic.[2][3] Su dose quotidian admissibile es fixate per le FDA a 15 mg/kg de massa corporal.

Un studio toxicologic in vitro monstra que le sucralosa-6-acetate, un producto de digestion del sucralosa, es genotoxic e le consumption de un soda edulcorate per die suffice a exceder le dose admissibile pro un producto genotoxic. Sucralose-6-acetate augmenta significativemente le expression de genes associate con inflammation, stress oxydative o cancere (con superior expression del gene metallothioneina 1 G (MT1G)).[4]

Un consumption importante de sucralose poterea haber un effecto immunomodulatori.[5]

Referentias[modificar fonte]

  1. Derivation: Entitates: 1. (it) Sucralosio || 2. (es) Sucralosa || (pt) Sucralose || 3. (fr) Sucralose || 4. (en) Sucralose || Controlo: (de) Sucralose || (ru) Сукралоза || - (Extra): (la)
  2. "Critical review of the current literature on the safety of sucralose" (August 2017). Food and Chemical Toxicology 106 (Pt A): 324–355. doi:10.1016/j.fct.2017.05.047. PMID 28558975. 
  3. "Sucralose Non-Carcinogenicity: A Review of the Scientific and Regulatory Rationale" (16 November 2016). Nutrition and Cancer 68 (8): 1247–1261. doi:10.1080/01635581.2016.1224366. PMID 27652616. 
  4. Susan S. Schiffman, Elizabeth H. Scholl, Terrence S. Furey & H. Troy Nagle (2023-05-29). "Toxicological and pharmacokinetic properties of sucralose-6-acetate and its parent sucralose: in vitro screening assays". Journal of Toxicology and Environmental Health. doi:10.1080/10937404.2023.2213903. PMID 37246822. 
  5. Zani F, Blagih J, Gruber T, Buck MD, Jones N, Hennequart M, Newell CL, Pilley SE, Soro-Barrio P, Kelly G, Legrave NM, Cheung EC, Gilmore IS, Gould AP, Garcia-Caceres C, Vousden KH (March 2023). "The dietary sweetener sucralose is a negative modulator of T cell-mediated responses". Nature 615 (7953): 705–711. doi:10.1038/s41586-023-05801-6. PMID 36922598.