Sucralosa
| Sucralosa |
|---|
| instantia de: typo de entitate chimic[*] |
| subclasse de: organochlorine compound[*], carbohydrate derivative[*] |
|
|
| formula chimic: C₁₂H₁₉Cl₃O₈ |
| Commons: Sucralose |
Sucralosa[1] (E955) es un edulcorante artificial intense, discoperite in 1976. Su potere sucrante es circa 600 vices superior a isto del saccharosa. Es pauc caloric pro que le major parte ingerate non es decomponate per le corpore.
Es producite per chloration del saccharosa, reimplaciante selectivemente le gruppos hydroxy in le positiones C1, C4 e C6 pro formar un disaccharido 1,6-dichloro-1,6-didesoxyfructosa–4-chloro-4-desoxygalactosa.
Innocuitate
[modificar | modificar fonte]Sucralosa non es carcinogenic.[2][3] Su dose quotidian admissibile es fixate per le FDA a 15 mg/kg de massa corporal.
Un studio toxicologic in vitro monstra que le sucralosa-6-acetate, un producto de digestion del sucralosa, es genotoxic e le consumption de un soda edulcorate per die suffice a exceder le dose admissibile pro un producto genotoxic. Sucralose-6-acetate augmenta significativemente le expression de genes associate con inflammation, stress oxydative o cancere (con superior expression del gen metallothioneina 1 G (MT1G)).[4]
Un consumption importante de sucralose poterea haber un effecto immunomodulatori.[5]
Referentias
- ↑ Parola derivate de: en:Sucralose, es:Sucralosa + pt:Sucralose, fr:Sucralose, it:Sucralosio // de:Sucralose, ru:Сукралоза.
- ↑ “Critical review of the current literature on the safety of sucralose” (1 de augusto 2017). Food and Chemical Toxicology 106 (Pt A): 324–355. doi:. PMID: 28558975.
- ↑ “Sucralose Non-Carcinogenicity: A Review of the Scientific and Regulatory Rationale” (16 de novembre 2016). Nutrition and Cancer 68 (8): 1247–1261. doi:. PMID: 27652616.
- ↑ Susan S. Schiffman, Elizabeth H. Scholl, Terrence S. Furey & H. Troy Nagle (29 de maio 2023). “Toxicological and pharmacokinetic properties of sucralose-6-acetate and its parent sucralose: in vitro screening assays”. Journal of Toxicology and Environmental Health. doi:. PMID: 37246822.
- ↑ Zani F, Blagih J, Gruber T, Buck MD, Jones N, Hennequart M, Newell CL, Pilley SE, Soro-Barrio P, Kelly G, Legrave NM, Cheung EC, Gilmore IS, Gould AP, Garcia-Caceres C, Vousden KH (1 de martio 2023). “The dietary sweetener sucralose is a negative modulator of T cell-mediated responses”. Nature 615 (7953): 705–711. doi:. PMID: 36922598.