Acido deoxyribonucleic
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Acido deoxyribonucleic (ADN o DNA) es un acido nucleic que contine le genetic instructiones usate in le disvelopamento e functionamento de tote organismos vive cognoscite e alicun viruses. Le role principal de ADN molecules es memorar information de termo longe. ADN es comparate frequentemente con un set de cyanotypos, o un code, proque illo contine le instructiones necessari constructer altere componentes de cellulas, como proteines e molecules ARN (Acido Ribo-Nucleic). Le segmentes de ADN que supporta isto information genetic es nominate genes, ma altere sequences de ADN ha proposito structural, o es implicate in regulatate del uso de isto information genetic.
ADN es composite, (in chimia organic) de duo longe polymeros de unitos simple nominate nucleotides.
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[modificar] Proprietates
ADN es un polymer longe composito de unitos que se repeta, nominate nucleotides.[1][2] Le catena de ADN es 22 a 26 Ångströms large (2.2 to 2.6 nanometres), e uno nucleotide es 3.3 Å (0.33 nm) longe.[3]
In le organismos vive, ADN no exista como un molecule solo, ma como un par de molecules associate stricte.[4][5] Multiple nucleotide in ligamine, como in ADN, isto polymer es nominate polynucleotide.[6]
[modificar] Cannellaturas
Le helice duble es un spiral dextera. [8] [9]
[modificar] Historia de recerca de DNA
- Plus information: Historia de biologia molecular
ADN esseva primero isolate de le physician Swisse Friedrich Miescher que, in 1869, discoperiva un substantia microscopic in le pure de bandages chirurgic e nominava ille "nuclein".[10]
[modificar] Vide etiam
[modificar] Referentias
- ↑ Alberts, Bruce; Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter Walters (2002). Molecular Biology of the Cell; Fourth Edition. New York and London: Garland Science. ISBN 0-8153-3218-1. OCLC 145080076 48122761 57023651 69932405.
- ↑ Butler, John M. (2001). Forensic DNA Typing. Elsevier. ISBN 978-0-12-147951-0. OCLC 223032110 45406517.pp. 14–15.
- ↑ Mandelkern M, Elias J, Eden D, Crothers D (1981). "The dimensions of DNA in solution". J Mol Biol 152 (1): 153–61. doi:. PMID 7338906.
- ↑ Watson J, Crick F (1953). "Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid" (PDF). Nature 171 (4356): 737–8. doi:. PMID 13054692.
- ↑ Berg J., Tymoczko J. and Stryer L. (2002) Biochemistry. W. H. Freeman and Company ISBN 0-7167-4955-6
- ↑ Abbreviations and Symbols for Nucleic Acids, Polynucleotides and their Constituents IUPAC-IUB Commission on Biochemical Nomenclature (CBN), Accessed 03 Jan 2006
- ↑ Creato ab PDB 1D65
- ↑ Wing R, Drew H, Takano T, Broka C, Tanaka S, Itakura K, Dickerson R (1980). "Crystal structure analysis of a complete turn of B-DNA". Nature 287 (5784): 755–8. doi:. PMID 7432492.
- ↑ Pabo C, Sauer R (1984). "Protein-DNA recognition". Annu Rev Biochem 53: 293–321. doi:. PMID 6236744.
- ↑ Dahm R (2005). "Friedrich Miescher and the discovery of DNA". Dev Biol 278 (2): 274–88. doi:. PMID 15680349.
[modificar] Lectura in plus
- Clayton, Julie. (Ed.). 50 Years of DNA, Palgrave MacMillan Press, 2003. ISBN 978-1-4039-1479-8
- Judson, Horace Freeland. The Eighth Day of Creation: Makers of the Revolution in Biology, Cold Spring Harbor Laboratory Press, 1996. ISBN 978-0-87969-478-4
- Olby, Robert. The Path to The Double Helix: Discovery of DNA, first published in October 1974 by MacMillan, with foreword by Francis Crick; ISBN 978-0-486-68117-7; the definitive DNA textbook, revised in 1994, with a 9 page postscript.
- Ridley, Matt. Francis Crick: Discoverer of the Genetic Code (Eminent Lives) HarperCollins Publishers; 192 pp, ISBN 978-0-06-082333-7 2006
- Rose, Steven. The Chemistry of Life, Penguin, ISBN 978-0-14-027273-4.
- Watson, James D. and Francis H.C. Crick. A structure for Deoxyribose Nucleic Acid (PDF). Nature 171, 737–738, 25 April 1953.
- Watson, James D. DNA: The Secret of Life ISBN 978-0-375-41546-3.
- Watson, James D. The Double Helix: A Personal Account of the Discovery of the Structure of DNA (Norton Critical Editions). ISBN 978-0-393-95075-5
- Watson, James D. "Avoid boring people and other lessons from a life in science" (2007) New York: Random House. ISBN 978-0-375-41284-4
- Calladine, Chris R.; Drew, Horace R.; Luisi, Ben F. and Travers, Andrew A. Understanding DNA, Elsevier Academic Press, 2003. ISBN 978-0-12-155089-9
[modificar] Ligamines externe
Patrono:Portalpar Patrono:Spoken Wikipedia
- The Secret Life of DNA - DNA Music compositions
- The Register of Francis Crick Personal Papers 1938 - 2007 at Mandeville Special Collections Library, Geisel Library, University of California, San Diego
- DNA Interactive This site from the Dolan DNA Learning Center included dozens of animations as well as interviews with James Watson and others (requires Adobe Flash)
- DNA from the Beginning Another DNA Learning Center site on DNA, genes, and heredity from Mendel to the human genome project.
- Double Helix 1953–2003 National Centre for Biotechnology Education
- Double helix: 50 years of DNA, Nature
- Rosalind Franklin's contributions to the study of DNA
- U.S. National DNA Day — watch videos and participate in real-time chat with top scientists
- Genetic Education Modules for Teachers — DNA from the Beginning Study Guide
- Listen to Francis Crick and James Watson talking on the BBC in 1962, 1972, and 1974
- Patrono:PDB Molecule of the Month
- Patrono:Proteopedia
- DNA under electron microscope
- Patrono:Dmoz
- DNA coiling to form chromosomes
- DISPLAR: DNA binding site prediction on protein
- Dolan DNA Learning Center
- Olby, R. (2003) "Quiet debut for the double helix" Nature 421 (January 23): 402–405.
- Basic animated guide to DNA cloning
- DNA the Double Helix Game From the official Nobel Prize web site
- DNA Lab, demonstrates how to extract DNA from wheat using readily available equipment and supplies.
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