Orthoflavivirus encephalitidis
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 O. encephalitidis a different pH nivellos.
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| Orthoflavivirus encephalitidis ICTV, 2022 | ||||||||||||||
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Orthoflavivirus encephalitidis (ex Tick-borne encephalitis virus) es un specie de virus del familia Flaviviridae. Es un arbovirus (arthropodoportate virus) transmittite per ticcas dur. Pote infectar plure typos de mammiferos e causar le encephalite ticcaportate in human. Se distingue al minus 3 subtypos, associate con differente species de ticca.
Transmission
[modificar | modificar fonte]Vector: le virus es transmittite per ticcas del genere Ixodes.
Reservoir: su hospites primari poterea esser ticcas ipse, rodentes o insectivoros.[1]
Hospites: primates (cuje Human), ruminantes, cavallos, rodentes, carnivoros (cuje can) ma alsi aves e ipse le mosquito Aedes vexans.[2]
Un transmission alimentari per le lacte non pasteurisate de ruminante infectate es possibile.[1]
Virologia
[modificar | modificar fonte]Es un virus de ARN de singulo filamento de senso positive. Su genoma es longe de circa 11 kb.[3]
Orthoflavivirus encephalitidis admitte al minus tres subtypos:
- West Europa subtypo, principalmente transmittite per Ixodes ricinus;
- Siberian subtypo, principalmente transmittite per Ixodes persulcatus;
- Est Asia subtypo, principalmente transmittite per Ixodes persulcatus.[4]
Subtypos baikalian e himalayan son alsi proposate.[5]
Le cippo de referentia es Sofjin cippo.[6]
Pathogenicitate
[modificar | modificar fonte]Le virus es pathogene. Duo casos sur tres son asymptomatic. Le maladia pote esser biphasic con un prime phase affectante cellulas cutanee e lymphatic glandulas. In le secunde phase, le virus traversa le hematoencephalic barriera producente neuronal inflammation in le systema nervose central (meningite (principalmente in infantes), meningoencephalite, meningoencephalomyelite, paralyse flaccide (poliomyelite), polyradiculonevrite (syndrome de Guillain-Barré) o formas hemorrhagic). Neurologic sequelas affecta de 26 % ad 46 % de casos.[2]
Le typo Est-asiatic pare esser le plus virulente con un rata de mortalitate de 5 % ad 40 % contra 6 % ad 8 % con le typo siberian e de 1 % ad 2 % con le typo europee.[2]
Vaccination
[modificar | modificar fonte]Nove vaccinos permitte le vaccination del population in regiones endemic.
Referentias
[modificar fonte]- ↑ 1,0 1,1 Salat J, Ruzek D. Tick-borne encephalitis in domestic animals. Acta Virol. 2020;64(2):226-232. doi:10.4149/av_2020_212. PMID: 32551790.
- ↑ 2,0 2,1 2,2 https://www.canada.ca/fr/sante-publique/services/biosecurite-biosurete-laboratoire/fiches-techniques-sante-securite-agents-pathogenes-evaluation-risques/virus-encephalite-tiques.html
- ↑ Thomas, S. J., T. P. Endy, A. L. Rothman, et A. D. Barrett. 2015. Flaviviruses (Dengue, Yellow Fever, Japanese Encephalitis, West Nile Encephalitis, St. Louis Encephalitis, Tick-Borne Encephalitis, Kyasanur Forest Disease, Alkhurma Hemorrhagic Fever, Zika), p. 1881. J. E. Bennett, R. Dolin, and M. J. Blaser (eds.), Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 8e ed.,. Elsevier.
- ↑ (2005) "Tick-Borne Encephalitis", Tick-Borne Diseases of Humans. Washington, DC: ASM Press, 151. ISBN 978-1-55581-238-6.
- ↑ "Tick-borne encephalitis in Europe and Russia: Review of pathogenesis, clinical features, therapy, and vaccines" (in en) . Antiviral Research 164: 23-51. doi:. ISSN 0166-3542. PMID 30710567. Wikidata Q91314251.
- ↑ "Tick-borne encephalitis virus: reference strain Sofjin and problem of its authenticity" (April 2012). Virus Genes 44 (2): 217–224. doi:. PMID 22095094.