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Netrina 1

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Netrina-1 es un proteina incodate in humanes per le gen NTN1 sul chromosoma 17.[1][2]

Netrina es parte de un familia de laminina-relative proteinas secretate. Se pensa que netrina-1 es implicate in axon guidantia (principalemente de axones commissural in le tubo neural) e cellular migration durante embryogenese. Mutationes e perta de expression del gene suggere un implication in cancerogenese.[2]

Un mutation del gene NTN1 serea responsabile del disordine congenital de movimentos speculee (en).[3]

Le rata urinari de netrina serea un marcator precoce del insufficientia renal acute.[4]

Durante un hepatite acute, netrina serea superexprimite et sustenerea le inflammation[5].

Scopo therapeutic

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Le anticorpore NP137 de Netris Pharma bloca netrina-1 e inhibi in consequentia le epithelial ad mesenchymal transition implicate in tumor initiation, progression, metastases e resistentia al tractamentos.[6][7][8]

Referentias

  1. ↑ “Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas” (1 de januario 1999). Cell Growth Differ. 10 (1): 35–42. PMID: 9950216.
  2. 1 2 Entrez Gene: NTN1 netrin 1.
  3. ↑ Méneret A, Franz EA, Trouillard O et al. Mutations in the netrin-1 gene cause congenital mirror movements, J Clin Invest, 2017;127:3923-3936
  4. ↑ Ramesh G, Krawczeski CD, Woo JG, Wang Y, Devarajan P, Urinary netrin-1 is an early predictive biomarker of acute kidney injury after cardiac surgery, Clin J Am Soc Nephrol, 2010;5:395–401
  5. ↑ La nétrine-1, un nouvel acteur dans l’inflammation hépatique ⋅ Inserm, La science pour la santé. Inserm (16 de maio 2022).
  6. ↑ Mélanie Bellina & Agnès Bernet (29 de april 2022). “La nétrine-1, une nouvelle cible antitumorale”. Med Sci. doi:10.1051/medsci/2022038.
  7. ↑ Lengrand, J., Pastushenko, I., Vanuytven, S. et al. (2 de augusto 2023). “Pharmacological targeting of netrin-1 inhibits EMT in cancer”. Nature. doi:10.1038/s41586-023-06372-2.
  8. ↑ Cassier, P.A., Navaridas, R., Bellina, M. et al. (2 de augusto 2023). “Netrin-1 blockade inhibits tumour growth and EMT features in endometrial cancer”. Nature. doi:10.1038/s41586-023-06367-z.
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