Netrina 1
Netrina-1 es un proteina incodate in humanes per le gene NTN1 sul chromosoma 17.[5][6]
Netrina es parte de un familia de laminina-relative proteinas secretate. Se pensa que netrina-1 es implicate in axon guidantia (principalemente de axones commissural in le tubo neural) e cellular migration durante embryogenese. Mutationes e perta de expression del gene suggere un implication in cancerogenese.[6]
Pathologia[modificar | modificar fonte]
Un mutation del gene NTN1 serea responsabile del disordine congenital de movimentos speculee (en).[7]
Le rata urinari de netrina serea un marcator precoce del insufficientia renal acute.[8]
Durante un hepatite acute, netrina serea superexprimite et sustenerea le inflammation[9].
Scopo therapeutic[modificar | modificar fonte]
Le anticorpore NP137 de Netris Pharma bloca netrina-1 e inhibi in consequentia le epithelial ad mesenchymal transition implicate in tumor initiation, progression, metastases e resistentia al tractamentos.[10][11][12]
Referentias[modificar fonte]
- ↑ 1,0 1,1 1,2 GRCh38: Ensembl release 89: ENSG00000065320 - Ensembl, May 2017
- ↑ 2,0 2,1 2,2 GRCm38: Ensembl release 89: ENSMUSG00000020902 - Ensembl, May 2017
- ↑ Human PubMed Reference:.
- ↑ Mouse PubMed Reference:.
- ↑ "Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas" (January 1999). Cell Growth Differ. 10 (1): 35–42. PMID 9950216.
- ↑ 6,0 6,1 Entrez Gene: NTN1 netrin 1.
- ↑ Méneret A, Franz EA, Trouillard O et al. Mutations in the netrin-1 gene cause congenital mirror movements, J Clin Invest, 2017;127:3923-3936
- ↑ Ramesh G, Krawczeski CD, Woo JG, Wang Y, Devarajan P, Urinary netrin-1 is an early predictive biomarker of acute kidney injury after cardiac surgery, Clin J Am Soc Nephrol, 2010;5:395–401
- ↑ La nétrine-1, un nouvel acteur dans l’inflammation hépatique ⋅ Inserm, La science pour la santé. Inserm (2022-05-16).
- ↑ Mélanie Bellina & Agnès Bernet (2022-04-29). "La nétrine-1, une nouvelle cible antitumorale". Med Sci. doi:.
- ↑ Lengrand, J., Pastushenko, I., Vanuytven, S. et al. (2023-08-02). "Pharmacological targeting of netrin-1 inhibits EMT in cancer". Nature. doi:.
- ↑ Cassier, P.A., Navaridas, R., Bellina, M. et al. (2023-08-02). "Netrin-1 blockade inhibits tumour growth and EMT features in endometrial cancer". Nature. doi:.