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Fibromyalgia

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Fibromyalgia es un medical condition characterisate per chronic diffuse dolor, fatiga, evelia non reposate, cognitive symptomas, dolor o crampos in basse abdomine, e depression.[1] Altere symptomas include insomnia[2] e hypersensibilitate.[3][4]

Affecta inter 2 e 4% del population, principalmente feminas.

Etiologia

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Su causa non es cognite, ma non serea psychosomatic; poterea implicar genetic e ambiente factores[4], como stress psychologic, trauma o alcun infectiones.[4] Dolor resultarea de processos in central nervo systema e le condition es considerate como un "syndrome de sensibilisation central".[5][6]

Desde 2021, alcun studios suggera un origine autoimmun del desordine, implicante neutrophilos, cellulas implicate in le responsa immun innate e producente cytokinas responsibile de inflammation.[7][8]

Referentias

  1. ↑ Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Häuser W, Katz RL, Mease PJ, Russell AS, Russell IJ, Walitt B (1 de decembre 2016). “2016 Revisions to the 2010/2011 fibromyalgia diagnostic criteria”. Seminars in Arthritis and Rheumatism 46 (3): 319–329. doi:10.1016/j.semarthrit.2016.08.012. PMID: 27916278.
  2. ↑ Wu YL, Chang LY, Lee HC, Fang SC, Tsai PS (1 de maio 2017). “Sleep disturbances in fibromyalgia: A meta-analysis of case-control studies”. Journal of Psychosomatic Research 96: 89–97. doi:10.1016/j.jpsychores.2017.03.011. PMID: 28545798.
  3. ↑ Häuser W, Sarzi-Puttini P, Fitzcharles MA (18 de februario 2019). “Fibromyalgia syndrome: under-, over- and misdiagnosis”. Clinical and Experimental Rheumatology 37 (1 Suppl 116): 90–97. PMID: 30747096.
  4. ↑ Arnold LM, Bennett RM, Crofford LJ, Dean LE, Clauw DJ, Goldenberg DL, Fitzcharles MA, Paiva ES, Staud R, Sarzi-Puttini P, Buskila D, Macfarlane GJ (1 de junio 2019). “AAPT Diagnostic Criteria for Fibromyalgia”. The Journal of Pain 20 (6): 611–628. doi:10.1016/j.jpain.2018.10.008. PMID: 30453109.
  5. ↑ Clauw DJ (1 de april 2014). “Fibromyalgia: a clinical review”. JAMA 311 (15): 1547–1555. doi:10.1001/jama.2014.3266. PMID: 24737367.
  6. ↑ Mezhov V, Guymer E, Littlejohn G (1 de decembre 2021). “Central sensitivity and fibromyalgia”. Internal Medicine Journal 51 (12): 1990–1998. doi:10.1111/imj.15430. PMID: 34139045.
  7. ↑ https://trustmyscience.com/fibromyalgie-origine-auto-immune-invasion-cellules-immunitaires/
  8. ↑ doi:10.1073/pnas.22116311
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