AOH1996
| AOH1996 |
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| instantia de: type of chemical entity[*] |
| subclasse de: composito chimic |
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AOH1996 es un chimiotherapia experimental anticancere. Iste molecula inhibi un forma particular del antigene nuclear del cellulas proliferante (en) (PCNA), qui es specific al cellulas canceree.[1][2][3][4]
Le proteina PCNA es crucial pro reparar le ADN de omne cellulas. Le tractamento presenta le interesse de affectar solmente cellulas tumoral.[5] Poterea ager contra canceres del pectore, prostata, cerebro, ovarios, collo uterin, pelle e pulmon.[6][7]
Su nomine es un hominaje a Anna Olivia Healy, un filia de 9 annos morte in 2006 de consequentias de un neuroblastoma. Le fundos colligite per su parentes ha adjutate a disveloppar iste medicamento.[6][8]
Referentias
[modificar fonte]- ↑ Malkas LH, et al. PCNA Inhibitors. Patent WO 2017/049206
- ↑ "Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination" (March 2023). Cell Reports 42 (4): 112296. PMID 36961817.
- ↑ "Small molecule targeting of transcription-replication conflict for selective chemotherapy" (August 2023). Cell Chemical Biology. doi:.
- ↑ AOH1996 for the Treatment of Refractory Solid Tumors.
- ↑ "The Anticancer Activity of a First-in-class Small-molecule Targeting PCNA" (December 2018). Clinical Cancer Research 24 (23): 6053–6065. PMID 29967249.
- ↑ 6,0 6,1 Anna (9) starb an Krebs – jetzt ist die Wunderpille nach ihr benannt (germano). 20 Minuten (2023-08-02).
- ↑ 'Cancer-killing pill' that appears to 'annihilate' solid tumours is now being tested on humans (anglese).
- ↑ AOH-1996 Is Here!. ANNA Fund (2021-12-21).